Which type of cancer is considered a classic example of X-ray induced malignancy?

Leukemia is considered a classic example of X-ray induced malignancy due to several key factors that have been observed in epidemiological studies. X-rays have the capability to cause genetic mutations and chromosomal abnormalities, which are critical in the development of blood cancers like leukemia. Research has demonstrated a clear association between exposure to ionizing radiation, including X-rays, and an increased incidence of various types of leukemia, particularly in populations that have undergone radiation therapy or have been exposed to high levels of radiation from other sources.

The biological mechanisms involve the direct damage to the DNA within the blood-forming organs such as the bone marrow, leading to uncontrolled cell proliferation and ultimately resulting in leukemia. The latency period for radiation-induced leukemia can range from several years to decades, but the link has been well established, making leukemia the most frequently cited example of malignancy associated with X-ray exposure. This association has been documented in survivors of atomic bomb blasts, individuals undergoing radiation therapy for other cancers, and workers in certain industries with occupational exposure to X-rays and other forms of ionizing radiation.