The major concern related to ultraviolet radiation within humans is primarily with:

The primary concern related to ultraviolet (UV) radiation in humans is skin cancer. UV radiation, which is emitted by the sun and artificial sources like tanning beds, can damage the DNA in skin cells. Over time, this damage can lead to mutations that result in various forms of skin cancer, including melanoma, the most serious type, as well as basal cell and squamous cell carcinomas.

Skin cells are particularly susceptible to UV radiation because they are directly exposed to sunlight. People who spend significant time outdoors without adequate protection, such as sunscreen, hats, or protective clothing, are at a higher risk. Additionally, factors such as lighter skin tone, history of sunburns, and genetic predispositions can further increase an individual's risk of developing skin cancer from UV exposure.

While cataracts and other forms of cancer are valid health concerns associated with UV radiation, such as damages in the eyes and potential connections to other cancer types, skin cancer remains the most direct and prevalent manifestation of damage caused by ultraviolet exposure, making it the major concern among the options provided.